Opportunity Information: Apply for EPA G2023 ORD F1
This Environmental Protection Agency (EPA) grant opportunity, titled "National Priorities: Evaluation of Antimicrobial Resistance in Wastewater and Sewage Sludge Treatment and Its Impact on the Environment" (Funding Opportunity Number: EPA G2023 ORD F1; CFDA/Assistance Listing: 66.511), funds research focused on antimicrobial resistance (AMR) as it relates to municipal wastewater and sewage sludge (biosolids). The core concern behind the program is that antibiotic resistant bacteria (ARB) and antibiotic resistant genes (ARGs) are increasingly being detected in places where people and animals can be exposed, and that this resistance can make infections harder to treat. EPA is treating wastewater treatment facilities as a key point of interest because they can receive resistant organisms and genes from many upstream sources and may also release them into the environment through treated effluent or through the handling and land application of biosolids, effectively acting as a pathway or "bridge" between human activity and natural waters and soils.
The main research aim is to close specific knowledge gaps about how ARB and ARGs occur, survive, move, and persist across wastewater systems and after discharge. EPA is looking for studies that track the occurrence and levels of resistant organisms and genes in municipal wastewater effluent and in biosolids, and then follow what happens to them through treatment processes and into receiving environments. This includes fate and transport questions such as whether resistant organisms are being reduced or selected for during treatment, how long they persist after release, how they move through aquatic systems and sediments, and what factors (treatment type, operational conditions, seasonal changes, disinfection approaches, etc.) appear to drive increases or decreases in ARB/ARG abundance and diversity. The intent is not only to document presence, but to understand mechanisms: selection pressures inside treatment trains, removal efficiencies across unit processes, and conditions that might promote persistence or regrowth after treatment.
In addition to traditional municipal treatment plants, EPA explicitly calls out several wastewater scenarios that often receive less research attention but may contribute meaningfully to environmental AMR: combined sewer overflows (CSOs), septic systems, and small wastewater systems. CSOs are particularly important during storm events when untreated or partially treated sewage may be released directly to surface waters. Septic and small systems matter because they are widespread, vary greatly in design and maintenance, and may discharge to groundwater or nearby surface waters with limited treatment. Proposals that examine these systems can help fill an important gap in understanding AMR sources outside large centralized plants.
A major priority is improving understanding of impacts on receiving waters and placing wastewater-related AMR in context among other sources. EPA wants research that helps quantify the relative contribution of ARB and ARGs from wastewater compared with other major inputs such as animal agriculture and animal husbandry operations, hospitals and healthcare facilities, and direct industrial sources. This comparative framing matters because environmental AMR is usually a mix of inputs, and decision-makers need to know when wastewater discharges are the dominant driver versus when other sources are more influential. Studies that use source tracking, comparative monitoring across watersheds, or integrated modeling approaches can help establish where wastewater fits into the overall AMR load and risk profile in a given region.
Beyond monitoring and mechanistic studies, the opportunity places strong emphasis on translating findings into usable risk-oriented tools. EPA is seeking frameworks and methodologies to quantify risk related to AMR in several practical settings: treated wastewater discharge to surface waters, water reuse applications (where treated effluent is intentionally reused), and biosolids management including land application and beneficial use of biosolids products. In other words, the agency is looking for approaches that move from "what is present" to "what does it mean for exposure and risk," including ways to compare scenarios, characterize uncertainty, and support decisions about treatment upgrades, reuse practices, or biosolids handling and application methods.
Funding is offered as a discretionary grant under EPA's environmental research activities. The expected program size is up to four awards, with an award ceiling of $2,375,000 per award. The funding opportunity was created May 19, 2023, with an original closing date listed as August 16, 2023 (with the announcement directing applicants to Section IV for the authoritative closing date details). Eligibility is listed broadly as "Others," with additional clarification to be found in the funding announcement's eligibility section, implying that applicants should confirm whether their institution type and role meet EPA's requirements.
Overall, the grant is designed to improve scientific understanding of the nature and extent of antimicrobial resistance associated with wastewater effluent and biosolids, identify how treatment processes influence selection and removal, clarify how AMR moves into and behaves within the environment, and develop risk-quantification methods that can be used to guide wastewater discharge practices, water reuse programs, and biosolids land application in ways that better protect environmental and public health.Apply for EPA G2023 ORD F1
- The Environmental Protection Agency in the environment sector is offering a public funding opportunity titled "NATIONAL PRIORITIES: EVALUATION OF ANTIMICROBIAL RESISTANCE IN WASTEWATER AND SEWAGE SLUDGE TREATMENT AND ITS IMPACT ON THE ENVIRONMENT" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 66.511.
- This funding opportunity was created on May 19, 2023.
- Applicants must submit their applications by Aug 16, 2023 See Section IV of funding opportunity announcement for closing date information.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $2,375,000.00 in funding.
- The number of recipients for this funding is limited to 4 candidate(s).
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification).
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