Opportunity Information: Apply for CDC RFA GH 23 0011

This grant opportunity is a CDC-funded PEPFAR cooperative agreement focused on strengthening HIV prevention and treatment support for key populations (KP) in Zambia, with initial implementation starting in Lusaka Province. The overall purpose is to help Zambia sustain and expand progress toward HIV epidemic control by improving access to high-quality, community-based, and person-centered services for groups that face higher HIV risk and major barriers to care. The funding is designed to reach people who are often underserved by traditional health systems and who may avoid services because of stigma, discrimination, criminalization, or lack of KP-competent providers.

The NOFO defines key populations using the UNAIDS framework, emphasizing five primary groups: gay men and other men who have sex with men (MSM), sex workers, transgender people, people who inject drugs (PWID), and prisoners or other incarcerated people. These populations are highlighted because they experience disproportionate HIV vulnerability and frequently have less consistent access to prevention tools, HIV testing, treatment initiation, and long-term retention in care. A central theme of the opportunity is that HIV outcomes improve when services are delivered by organizations that understand these communities and can provide respectful, confidential, and culturally competent support.

The recipient is expected to provide direct service delivery and to do so in a way that is comprehensive and integrated rather than fragmented. The grant prioritizes engagement of KP-led organizations and other KP-competent implementers to deliver critical prevention interventions and treatment support. The work is intended to be community-based and sustainable, meaning it should be structured to build durable capacity, strengthen referral and follow-up systems, and reduce drop-off at every step of the HIV service continuum.

Programmatically, the NOFO centers on improving HIV-related outcomes through several linked service areas. One major focus is case finding and linkage: identifying KP who are living with HIV and ensuring effective linkage to facility-based and community-based treatment services. Beyond simply initiating treatment, the program emphasizes retention in care and ongoing support so clients can achieve and maintain sustained viral load suppression (VLS), which is essential for individual health and for reducing onward transmission. For KP who test HIV-negative, the opportunity stresses rapid linkage to biomedical prevention, especially pre-exposure prophylaxis (PrEP), so that individuals at ongoing risk have access to a proven prevention option with appropriate counseling, follow-up, and adherence support.

In addition to HIV testing, linkage, treatment support, and PrEP, the NOFO includes a wider prevention package aligned with comprehensive KP programming. This includes voluntary medical male circumcision (VMMC) where appropriate, cervical cancer prevention and treatment services (relevant to HPV and broader sexual and reproductive health needs), and condom programming to ensure availability, correct use education, and normalization of condom access in community settings. The scope also explicitly incorporates gender-based violence (GBV) prevention and response, recognizing that violence and coercion are both drivers and consequences of HIV vulnerability for many KP, and that survivors often need safe disclosure options, clinical services, psychosocial support, and referral pathways.

For people who inject drugs, the NOFO highlights harm reduction services, signaling an expectation that programming will address injection-related HIV transmission risks through evidence-based approaches and supportive linkages (for example, safer use education and pathways to additional health and social services, consistent with the local legal and policy environment). Taken together, these elements indicate the award is meant to deliver a full combination prevention model that connects behavioral, biomedical, and structural interventions, rather than relying on a single service line.

From an administrative and funding standpoint, this is a discretionary cooperative agreement (Funding Opportunity Number CDC RFA GH 23 0011) under CFDA 93.067, administered by the U.S. Department of Health and Human Services, Centers for Disease Control and Prevention (CDC), Center for Global Health. Eligibility is listed as unrestricted (open to any type of entity, subject to any additional eligibility language in the full announcement). CDC anticipated making one award. While the published “Award Ceiling for Year 1” is listed as 0 (none), the notice also states CDC anticipated approximately $900,000 in total funding for Year 1, contingent on the availability of funds. The original posting date was January 26, 2023, with an original application deadline of March 27, 2023, by 11:59 pm Eastern Time for electronic submissions.

Overall, the opportunity is aimed at ensuring that KP in Zambia, beginning in Lusaka Province, can access the same core prevention and treatment outcomes expected for the general population, but delivered through approaches that actually work for KP realities. The intent is to reduce missed diagnoses, speed up linkage to ART, improve retention and viral suppression among KP living with HIV, and expand effective prevention (especially PrEP) among KP who are HIV-negative, while also addressing related health needs and structural barriers such as GBV and injection-related risks.

  • The Department of Health and Human Services, Centers for Disease Control - CGH in the health sector is offering a public funding opportunity titled "Enhancing Comprehensive Community-Based and Sustainable HIV/AIDS Key Population (KP) Prevention Services and Treatment Support for KP Living with HIV in the Republic of Zambia under PEPFAR" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.067.
  • This funding opportunity was created on Jan 26, 2023.
  • Applicants must submit their applications by Mar 27, 2023 Electronically submitted applications must be submitted no later than 1159 pm ET on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The number of recipients for this funding is limited to 1 candidate(s).
  • Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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