Opportunity Information: Apply for RFA TR 22 013
The Emergency Awards: HEAL Initiative - New Innovator Award (DP2 Clinical Trial Not Allowed) is a National Institutes of Health (NIH) funding opportunity issued by the National Center for Advancing Translational Sciences (NCATS) in direct response to the federally declared public health emergency tied to the opioid crisis. The program sits under the broader Helping End Addiction Long-Term (HEAL) Initiative and is meant to accelerate bold, high-impact biomedical research that can change the trajectory of pain management, opioid use disorder (OUD), and overdose (OD) outcomes. The intent is not incremental progress or routine extensions of existing work, but genuinely novel ideas that could reshape thinking in the field or open new directions that are currently underexplored.
At its core, this opportunity supports postdoctoral researchers or newly independent Early Stage Investigators who show exceptional creativity and are ready to propose original research concepts with the potential for major impact. The emphasis is on innovation: projects that test scientific paradigms, challenge prevailing assumptions, or advance key concepts relevant to pain, OUD, and/or overdose. NCATS explicitly encourages proposals that bring together unexpected combinations of disciplines (for example, engineering plus behavioral science, computational methods plus clinical insight, or novel chemistry with implementation considerations), introduce new scientific directions, or rely on novel methodologies that could unlock faster or more effective solutions. Even though the program is framed as an emergency response, the scientific bar is still high and the expectation is that funded work will meaningfully move the broader research ecosystem forward.
A key limitation is embedded in the title: "Clinical Trial Not Allowed." That means applicants must design projects that do not meet NIH definitions of a clinical trial. In practical terms, the research can still be translational and human-relevant, but it must avoid interventional human studies where participants are prospectively assigned to an intervention to evaluate effects on health-related outcomes. This pushes applicants toward mechanistic studies, preclinical research, tool and technology development, data-driven analyses, observational approaches, or other non-trial designs that can still have clear relevance to pain, OUD, or overdose.
In terms of organizational eligibility, the FOA is broadly open across government, education, nonprofit, and private-sector entities in the United States. Eligible applicants include state, county, city or township governments, special district governments, independent school districts, and public housing authorities. It also includes public and state-controlled institutions of higher education, private institutions of higher education, nonprofits with or without 501(c)(3) status (outside higher education), for-profit organizations (other than small businesses), and small businesses. Tribal participation is also supported: federally recognized Native American tribal governments are eligible, as are Native American tribal organizations that are not federally recognized tribal governments. The FOA also highlights additional eligible categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), faith-based or community-based organizations, certain eligible federal agencies, regional organizations, and U.S. territories or possessions.
Foreign participation is explicitly restricted. Non-domestic (non-U.S.) entities and foreign institutions are not eligible to apply. In addition, non-domestic components of U.S. organizations are not eligible, and foreign components (as NIH defines them in its Grants Policy Statement) are not allowed. In effect, the work and the organizational structure must remain domestically based, without foreign subcomponents that NIH would treat as a foreign component of the project.
Administrative details in the source information indicate this is a discretionary grant mechanism under an NIH Funding Opportunity Announcement (FOA) numbered RFA-TR-22-013. The original closing date listed is April 19, 2023, and the maximum award amount (award ceiling) is $1,500,000. Multiple CFDA (now Assistance Listing) numbers are associated with the opportunity, reflecting NIH program authorities that can support this kind of research across translational science and health-related domains (including 93.213, 93.273, 93.350, 93.393, 93.846, 93.847, 93.853, 93.865, 93.866). While the source excerpt does not specify the exact number of expected awards, the ceiling indicates that NIH intends to fund substantial, ambitious projects with enough support to enable real leaps in capability or understanding.
Overall, the program can be read as an emergency-driven innovation engine: it targets early-career scientific leaders and asks them to bring forward daring, creative, methodologically fresh research ideas that could materially change how the biomedical community understands or addresses pain, opioid use disorder, and overdose, while staying within a non-clinical-trial scope and within strictly domestic eligibility boundaries.Apply for RFA TR 22 013
- The National Institutes of Health in the education, food and nutrition, health, income security and social services sector is offering a public funding opportunity titled "Emergency Awards: HEAL Initiative- New Innovator Award (DP2 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.213, 93.273, 93.350, 93.393, 93.846, 93.847, 93.853, 93.865, 93.866.
- This funding opportunity was created on 2022-01-20.
- Applicants must submit their applications by 2023-04-19. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $1,500,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
Browse more opportunities from the same category: Education, Food and Nutrition, Health, Income Security and Social Services
Next opportunity: Cooperative Agreement for CESU- affiliated Partner of the Pacific Northwest Cooperative Ecosystem Studies Unit (CESU)
Previous opportunity: Defense Production Act Title III Expansion of Domestic Production Capability and Capacity; CALL 011 - Critical Chemical Precursors for Energetic Materials
Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for RFA TR 22 013
Applicants also applied for:
Applicants who have applied for this opportunity (RFA TR 22 013) also looked into and applied for these:
| Funding Opportunity |
|---|
| HEAL Initiative: Discovery and Functional Evaluation of Human Pain-associated Genes and Cells (U19 Clinical Trial Not Allowed) Apply for RFA NS 22 018 Funding Number: RFA NS 22 018 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $1,500,000 |
| HEAL Initiative: Interdisciplinary Team Science to Uncover the Mechanisms of Pain Relief by Medical Devices (RM1 Clinical Trial Optional) Apply for RFA NS 23 003 Funding Number: RFA NS 23 003 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| HEAL Initiative: Development and Validation of Non-Rodent Mammalian Models of Pain(R01 Clinical Trial Not Allowed) Apply for RFA NS 22 070 Funding Number: RFA NS 22 070 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $750,000 |
| Catalyst Award for Early-Stage Investigators (ESIs) Pursuing Research on HIV Comorbidities, Coinfections, and Complications (DP1- Clinical Trial Optional) Apply for PAR 23 024 Funding Number: PAR 23 024 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $350,000 |
| Advanced Training in Artificial Intelligence for Precision Nutrition Science Research (AIPrN) Institutional Research Training Programs (T32) Apply for RFA OD 22 027 Funding Number: RFA OD 22 027 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Short Courses on Innovative Methodologies and Approaches in the Behavioral and Social Sciences (R25 Independent Clinical Trial Not Allowed) Apply for RFA OD 23 003 Funding Number: RFA OD 23 003 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $200,000 |
| Enhancing the Use of the All of Us Research Programs Data (R21 Clinical Trial Not Allowed) Apply for RFA PM 23 001 Funding Number: RFA PM 23 001 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Small Grants to Enhance the Use of the All of Us Research Programs Data (R03 Clinical Trial Not Allowed) Apply for RFA PM 23 002 Funding Number: RFA PM 23 002 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| NIH Science Education Partnership Award (SEPA) (R25 - Clinical Trial Not Allowed) Apply for PAR 23 137 Funding Number: PAR 23 137 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $250,000 |
| Emergency Awards: HEAL Initiative- New Innovator Award (DP2 Clinical Trial Not Allowed) Apply for RFA TR 23 011 Funding Number: RFA TR 23 011 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $1,500,000 |
| HEAL Initiative: Interdisciplinary Team Science to Uncover the Mechanisms of Pain Relief by Medical Devices (RM1 Clinical Trial Optional) Apply for RFA NS 23 028 Funding Number: RFA NS 23 028 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $1,500,000 |
| HEAL Initiative: HEAL KIDS (Knowledge, Innovation and Discovery Studies) Pain: Acute Pain Clinical Trials Program (U01 Clinical Trial Required) Apply for RFA HD 24 011 Funding Number: RFA HD 24 011 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| HEAL Initiative: Non-addictive Analgesic Therapeutics Development [Small Molecules and Biologics] to Treat Pain (UG3/UH3 Clinical Trial Optional) Apply for RFA NS 24 019 Funding Number: RFA NS 24 019 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Stephen I. Katz Early Stage Investigator Research Project Grant (R01 Clinical Trial Not Allowed) Apply for PAR 24 075 Funding Number: PAR 24 075 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Stephen I. Katz Early Stage Investigator Research Project Grant (R01 Basic Experimental Studies with Human Required) Apply for PAR 24 076 Funding Number: PAR 24 076 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| HEAL Initiative: Studies to Enable Analgesic Discovery (R61/R33 - Clinical Trial Not Allowed) Apply for RFA NS 25 012 Funding Number: RFA NS 25 012 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $350,000 |
| Advancing HIV service delivery through pharmacies and pharmacists (R01 Clinical Trial Optional) Apply for RFA MH 25 185 Funding Number: RFA MH 25 185 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| NIH HEAL Initiative PainCare Clinician Training Program (PCTP): Mentored Clinical Scientist Development Awards (K08 - Clinical Trials Required) Apply for PAR 24 217 Funding Number: PAR 24 217 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Time-Sensitive Obesity Policy and Program Evaluation (R01) Apply for PAR 15 346 Funding Number: PAR 15 346 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| HEAL Initiative: Studies to Enable Analgesic Discovery (R61/R33 - Clinical Trial Not Allowed) Apply for RFA NS 25 023 Funding Number: RFA NS 25 023 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $350,000 |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Inside Our Applicants Portal
Access Applicants Portal
- Grants Repository - Access current and historic funding opportunities with ease. Thousands of funding opportunities are published every week. We can help you sort through the database and find the eligible ones to apply for.
- Applicant Video Guides - The grant application process can be challenging to follow. We can help you with intuitive video guides to speed up the process and eliminate errors in submissions.
- Grant Proposal Wizard - We have developed a network of private funding organizations and investors across the United States. We can reach out and submit your proposal to these contacts to maximize your chances of getting the funding you need.
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Learn More
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "RFA TR 22 013", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.